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Conformational changes of these conserved residues especially the transmission switch residues F272 6.44 and W276 6.48 have been suggested to link the extracellular agonist-binding to the cytoplasmic receptor activation and G protein-coupling for class A GPCRs (Supplementary Fig

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doi: 10.1038/s41401-024-01359-9 66 WangFGmez-SintesRBoyaP

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